BRD Antimicrobial Comparison Chart

DRAXXIN is the most effective antibiotic for BRD treatment and prevention, according to multiple studies. 123

To find the most effective solution for your operation, explore the BRD Solutions portfolio, including DRAXXIN, EXCEDE and ADVOCIN.

Product
Associated with:
Mannheimia haemolytica
Associated with:
Pasteurella multocida
Associated with:
Histophilus somni
Associated with:
Mycoplasma bovis
Dosage
(per cwt)
Estimated Duration
Meat Withdrawal
(days)
 
Control
Treat
Control
Treat
Control
Treat
Control
Treat
     
(tulathromycin)
Yes Yes Yes Yes Yes Yes Yes Yes 1.1 mL 14 days 47 18
(ceftiofur crystalline free acid)
Yes Yes Yes Yes Yes Yes No No 1.5 ml 7 days 6,8 13
(danofloxacin injection)
Yes Yes Yes Yes No No No No 1.5–2 mL ** 4
Other Products
Baytril®
(enrofloxacin)
Yes Yes Yes Yes Yes Yes Yes Yes 3.4–5.7 mL ** 28
Micotil®
(tilmicosin)
Yes Yes No Yes No Yes No No 1.5–3 mL ** 42
Nuflor®
(florfenicol)
Yes Yes Yes Yes Yes Yes No No 3–6 mL **
38 (SC)
28 (IM)
Zactran®
(gamithromycin)
Yes Yes Yes Yes No Yes No Yes 1.82 mL 10 days 9,10 35
Zuprevo®
(tildipirosin)
Yes Yes Yes Yes Yes Yes No No 1 mL ** 21

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Safety Information

IMPORTANT SAFETY INFORMATION FOR DRAXXIN: DRAXXIN has a pre-slaughter withdrawal time of 18 days. Do not use in female dairy cattle 20 months of age or older. Do not use in animals known to be hypersensitive to the product. Full Prescribing Information

IMPORTANT SAFETY INFORMATION FOR EXCEDE: People with known hypersensitivity to penicillin or cephalosporins should avoid exposure to EXCEDE. EXCEDE is contraindicated in animals with known allergy to ceftiofur or to the ß-lactam group (penicillins and cephalosporins) of antimicrobials. Inadvertent intra-arterial injection is possible and fatal. Do not use in calves to be processed for veal. Pre-slaughter withdrawal time is 13 days following the last dose. Full Prescribing Information

IMPORTANT SAFETY INFORMATION FOR ADVOCIN: Extra-label use of ADVOCIN in food-producing animals is prohibited. Do not use in cattle intended for dairy production or in calves to be processed for veal. ADVOCIN has a pre-slaughter withdrawal time of four days. Full Prescribing Information

**Clinical data not available in literature. 

  1. O’Connor AM, Yuan C, Cullen JN, Coetzee JK, da Silva N, Wang C. A mixed treatment meta-analysis of antibiotic treatment options for bovine respiratory disease — An Update. Prev Vet Med. 2016;132:130-139. 
  2. Abell KM, Theurer ME, Larson RL, White BJ, Apley M. A mixed treatment comparison meta-analysis of metaphylaxis treatments for bovine respiratory disease in beef cattle. J Anim Sci. 2017;95(2):626-635. 
  3. Nautrup BP, Van Vlaenderen I, Decker M, Cleale RM. Antimicrobial drug use for control and treatment of bovine respiratory disease in U.S. feedlot cattle: A meta-analysis of comparative studies versus tulathromycin. Bov Pract. 2017 (in press). 
  4. Freedom of Information Summary. NADA 141-244. Available at: http://www.fda.gov/downloads/animalveterinary/products/approvedanimaldrugproducts/foiadrugsummaries/ucm118061.pdf. Accessed April 10, 2017. 
  5. Data on file, Study Report No. 1131R-60-05-485, Zoetis Inc. 
  6. Data on file, Study Report No. 1133R-60-05-489, Zoetis Inc. 
  7. Data on file, Study Report No. 1133R-60-09-749, Zoetis Inc. 
  8. Hibbard B, Meeuwse D, Bryson WL, et al. EXCEDE vs. Micotil for control of bovine respiratory disease using a post-metaphylaxis interval. Study Report Nos. SR-0829-7922-2003-007 and SR-0829-7922-2002-003, Zoetis Inc. 
  9. Lechtenberg K, Daniels CS, Royer GC, et al. Field Efficacy Study of Gamithromycin for the Control of Bovine Respiratory Disease in Cattle at High Risk of Developing the Disease. Intern J Appl Res Vet Med. 2011;9(2):189-197. 
  10. Sifferman RL, Wolff WA, Holste JE, et al. Field Efficacy Evaluation of Gamithromycin for Treatment of Bovine Respiratory Disease in Cattle at Feedlots. Intern J Appl Res Vet Med. 2011;9(2):166-175.